Sepsis Clinical Guide

Sepsis is a serious systemic infection that can quickly lead to circulatory shock, organ failure and death if inappropriately treated. It is also a serious problem in hospitals throughout the US and the world. In 2013, 1.3 million people were admitted to US hospitals for sepsis (#1 cause of index admissions!) at a total cost to the US healthcare system of $23.7 billion dollars (#1 most expensive condition!). Over 250,000 people die of sepsis in the US every year, more than from prostate cancer, breast cancer and AIDS combined. Despite its large toll on public health, public awareness of this condition is poor and the quality of treatment is highly variable often due to late recognition and treatment.

In sepsis, time is of the essence. Successful treatment hinges on prompt recognition of symptoms, correct antibiotic administration, and hemodynamic stabilization. Lack of appropriate sepsis management knowledge at the bedside leads to delayed symptom recognition, serious complications, medical errors, increased treatment costs, and avoidable morbidity and mortality. For this reason, we created this app to provide busy health professionals with essential management information based on the latest practice guidelines in a format that is easily accessible at the point of care.

The Sepsis app features search, annotation, bookmarking functions and calculator support. All content is extensively referenced and footnoted where appropriate, and periodically updated. This app remains free of charge due to the generous sponsorship of Beckman Coulter.

Clinical topics covered in the Sepsis app include:

- The latest definitions and clinical guidelines including Sepsis-3 and the 2016 Surviving Sepsis Campaign (SSC) guidelines

- Epidemiology, risk factors and pathophysiology of sepsis and septic shock

- Common differentials and etiology, guidelines on performing appropriate H&P and workups

- Management of common causes including hospital-acquired pneumonia (HAP), ventilator-acquired pneumonia (VAP) and intra-abdominal infections

- Sepsis management bundles, early goal-directed therapy, hemodynamic management, adjunctive therapies, mechanical ventilation of sepsis-induced ARDS, and other essential management guidelines from the SSC and the American Thoracic Society (ATS)

- Antibiotic therapy including specific guidelines for the treatment of HAP from ATS and the Infectious Diseases Society of America (IDSA)

- Diagnosis and management of pediatric and neonatal sepsis including the management of pediatric fever, important differences from management of sepsis in adults, management of sepsis-induced persistent pulmonary hypertension of the newborn (PPHN), empiric antibiotic treatment recommendations for GBS infections, interventions in pediatric septic shock, and other pediatric-specific information

- Important calculators including the Sequential Organ Failure Assessment (SOFA), quick-SOFA, APACHE II, Multiple Organ Dysfunction Score (MODS), the Simplified Acute Physiology Score (SAPS) II, the National Early Warning Score (NEWS), the Clinical Pulmonary Infection (CPI) score, the Inferior Vena Cava Collapsibility Index, and others

- Drug administration information including antibacterial and antifungal antibiotics, adrenergic and other vasoactive agents, corticosteroids and diuretics

Recommended by:

- Top US doctors on HealthTap

- MDLinx.com

- imedicalapps.com

- The Russian Sepsis Forum (sepsisforum.ru)

- The ED Trauma Critical Care Blog (edtcc.com)

败血症是一种严重的全身性感染，可迅速导致循环性休克，器官功能衰竭而死亡，如果处理不当。这也是整个美国和世界的医院一个严重的问题。在2013年，130万人的总费用为$ 23.7十亿美元的美国医疗系统被送往美国败血症医院（＃1原因指数招生的！）（＃1最贵的条件！）。超过25万人每年死于美国败血症，超过前列腺癌，乳腺癌和艾滋病合并。尽管对公众健康的大型收费，公众对这一疾病的意识差，治疗的质量往往是高度可变由于后期识别和治疗。

在败血症，时间是至关重要的。成功的治疗取决于及时识别的症状，正确使用抗生素，和血流动力学稳定。缺乏在床边适当败血症管理知识导致延迟症状的识别，严重的并发症，医疗差错，增加了治疗成本，避免发病率和死亡率。出于这个原因，我们创造了这个应用程序提供繁忙的卫生专业人员基于的格式，是在护理点容易获得最新的实践指南基本的管理信息。

败血症应用功能搜索，注释，书签功能和计算器的支持。所有的内容被广泛引用和脚注在适当情况下，并定期更新。这个程序仍然是免费的，由于Beckman Coulter公司的大手笔赞助。

覆盖在脓毒症的临床应用的主题包括：

- 最新的定义和临床指南包括败血症-3和2016年拯救脓毒症患者运动（SSC）指南

- 流行病学，危险因素和败血症和感染性休克的病理生理机制

- 常见的差异和病因，上进行适当的H＆P和workups指南

- 常见的原因包括医院获得性肺炎（HAP），呼吸机相关性肺炎（VAP）和腹腔内感染管理

- 脓毒症管理包，早期目标导向治疗，血液动力学管理，辅助治疗，败血症引起的急性呼吸窘迫综合征的机械通气，并从SSC和美国胸科协会等人体必需的管理准则（ATS）

- 抗生素治疗包括用于从ATS和美国传染病学会治疗HAP的具体的准则（IDSA）

- 诊断和管理儿科和新生儿败血症，包括小儿发烧的管理，从成人败血症管理的重要差异，新生儿（PPHN），对GBS感染的经验性抗生素治疗的建议，干预的败血症引起的持续性肺动脉高压管理小儿感染性休克，等小儿特定信息

- 重要计算器包括序贯器官衰竭评估（SOFA），快速SOFA，APACHE II，多器官功能障碍评分（MODS），简化的急性生理评分（SAPS）II，国家预警评分（NEWS），临床肺感染（CPI）的分数，下腔静脉溃散指数，以及其他

- 给药信息包括抗菌剂和抗真菌抗生素，肾上腺素和其它血管活性剂，皮质类固醇和利尿剂

被推荐：

- 在HealthTap美国顶尖医生

- MDLinx.com

- imedicalapps.com

- 俄罗斯脓毒症论坛（sepsisforum.ru）

- 教育署创伤重症监护博客（edtcc.com）